SeriesParkinson’sDisease1TheepidemiologyofParkinson’sdiseaseYoavBen-Shlomo,SirwanDarweesh,JorgeLlibre-Guerra,ConnieMarras,MartaSanLuciano,CarolineTannerTheepidemiologyofParkinson’sdiseaseshowsmarkedvariationsintime,geography,ethnicity,age,andsex.Lancet2024;403:283–92Internationally,prevalencehasincreasedoverandabovedemographicchanges.Thereareseveralpotentialreasonsforthisincrease,includingt...
SeriesParkinson’sDisease3Medical,surgical,andphysicaltreatmentsforParkinson’sdiseaseTomFoltynie,VeronicaBruno,SusanFox,AndreaAKühn,FionaLindop,AndrewJLeesAlthoughdopaminereplacementtherapyremainsacorecomponentofParkinson’sdiseasetreatment,theonsetofLancet2024;403:305–24motorfluctuationsanddyskineticmovementsmightrequirearangeofmedicalandsurgicalapproachesfromamultidisciplinaryteam,andimpor...
EditorialWhatnextinParkinson’sdisease?Morethan200yearssincethepublicationofJameswhichmightalsopavethewayforfurtherresearchonAmelie-Benoist/BSIP/SciencePhotoLibraryParkinson’sAnEssayontheShakingPalsy(1817),manydisease-modifyingtherapies.Meanwhile,clinicalstudiesuncertaintiesregardingtheprogressiveneurologicalofnewdrugstobettertreatdyskinesiaandothermotorForParkinson’soriginalessaydisordernowk...
SeriesParkinson’sDisease2ThepathogenesisofParkinson’sdiseaseHuwRMorris,MariaGraziaSpillantini,CarolynMSue,CarolineHWilliams-GrayParkinson’sdiseaseisaprogressiveneurodegenerativeconditionassociatedwiththedepositionofaggregatedLancet2024;403:293–304α-synuclein.InsightsintothepathogenesisofParkinson’sdiseasehavebeenderivedfromgeneticsandmolecularpathology.Biochemicalstudies,investigationoftr...
